Sestrin2 maintains OXPHOS integrity to modulate cardiac substrate metabolism during ischemia and reperfusion
نویسندگان
چکیده
منابع مشابه
Graded global ischemia and reperfusion. Cardiac function and lactate metabolism.
The effect of global ischemia of different degrees of severity and reperfusion was studied in the isolated working rat heart. Four degrees of ischemia were induced by reducing the control total coronary flow of 8 ml/min to 0, 0.04, 0.4, or 0.8 ml/min for 30 minutes, after which the coronary flow was returned to the control level. After severe ischemia (0 and 0.04 ml/min ischemic coronary flow g...
متن کاملReperfusion after Cardiac Ischemia
Varadarajan, Srinivasan G., Jianzhong An, Enis Novalija, Steven C. Smart, and David F. Stowe. Changes in [Na]i, compartmental [Ca ], and NADH with dysfunction after global ischemia in intact hearts. Am J Physiol Heart Circ Physiol 280: H280–H293, 2001.—We measured the effects of global ischemia and reperfusion on intracellular Na, NADH, cytosolic and mitochondrial (subscript mito) Ca, relaxatio...
متن کاملMitochondrial K+ transport and cardiac protection during ischemia/reperfusion.
Mitochondrial ion transport, oxidative phosphorylation, redox balance, and physical integrity are key factors in tissue survival following potentially damaging conditions such as ischemia/reperfusion. Recent research has demonstrated that pharmacologically activated inner mitochondrial membrane ATP-sensitive K+ channels (mitoK(ATP)) are strongly cardioprotective under these conditions. Furtherm...
متن کاملDifferential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion.
BACKGROUND Fatty acid and glucose transporters translocate between the sarcolemma and intracellular compartments to regulate substrate metabolism acutely. We hypothesised that during ischemia fatty acid translocase (FAT/CD36) would translocate away from the sarcolemma to limit fatty acid uptake when fatty acid oxidation is inhibited. METHODS AND RESULTS Wistar rat hearts were perfused during ...
متن کاملMitochondrial Approaches to Protect Against Cardiac Ischemia and Reperfusion Injury
The mitochondrion is a vital component in cellular energy metabolism and intracellular signaling processes. Mitochondria are involved in a myriad of complex signaling cascades regulating cell death vs. survival. Importantly, mitochondrial dysfunction and the resulting oxidative and nitrosative stress are central in the pathogenesis of numerous human maladies including cardiovascular diseases, n...
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ژورنال
عنوان ژورنال: Redox Biology
سال: 2021
ISSN: 2213-2317
DOI: 10.1016/j.redox.2020.101824